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Because the Kras G12D -Myc axis has been suggested to induce Nrf2 gene expression and increased the activity of Nrf2 in pancreatic cancers ( Another unique regulator of the pentose phosphate pathway is the tumor suppressor p53, which inhibits the pentose phosphate pathway through binding to G6PD and preventing the formation of the active dimer ( DETOXIFICATION OF ROS FOR CELL SURVIVAL AND PROLIFERATION The glutathione synthesis pathway is another important anabolic target of Nrf2 (MacLeod et al., 2009)

Anca Tchelebi-Moscatello, M.D

Others report no issues

Therefore, pathological analysis suggests that anti-tumor strategies based on energy metabolism could minimize macrophage phagocytosis for tumor inhibition in vivo